P2X7 (P2RX7) Rabbit Polyclonal Antibody

CAT#: TA349115

Rabbit Polyclonal Anti-P2RX7 Antibody

Product Images

Western blot analysis of P2RX7 in 3T3 cell lysate with P2RX7 antibody at (A) 1 and (B) 2 ug/mL.

• 

  Immunocytochemistry of P2RX7 in 3T3 cells with P2RX7 antibody at 5 ug/mL.

• 

  Immunofluorescence of P2RX7 in 3T3 cells with P2RX7 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: P2RX7 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 34, 47, 65 kDa; Observed: 54 kDa
• Gene Name: purinergic receptor P2X 7
• Database Link:
  NP_002553
  Entrez Gene 18439 MouseEntrez Gene 5027 Human
  UniProt ID Q99572
• Background: The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).
• Synonyms: P2X7

Reference Data

• Protein Families: Druggable Genome, Ion Channels: ATP Receptors, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction