CACNA1H Rabbit Polyclonal Antibody

CAT#: TA349119

Rabbit Polyclonal Anti-CACNA1H Antibody

Product Images

Western blot analysis of CACNA1H in 293 cell lysate with CACNA1H antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of CACNA1H in mouse brain tissue with CACNA1H antibody at 5 ug/mL.

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  Immunofluorescence of CACNA1H in mouse brain tissue with CACNA1H antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CACNA1H antibody was raised against a 16 amino acid peptide near the center of human CACNA1H.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CACNA1H antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 259 kDa; Observed: 260 kDa
• Gene Name: calcium voltage-gated channel subunit alpha1 H
• Database Link:
  NP_001005407
  Entrez Gene 58226 MouseEntrez Gene 114862 RatEntrez Gene 8912 Human
  UniProt ID O95180
• Background: The calcium channel protein CACNA1H is a T-type member of the alpha-1 subunit family that is part of the voltage-dependent calcium channel complex which mediates the influx of calcium ions into the cell upon membrane polarization (1,2). CACNA1H is a subunit of Cav3.2 T-type calcium channel that is involved in neurological disorders such as epilepsy and pain (2,3). CACNA1H associates with the caveolin protein Cav-3 and it is thought that Cav-3 regulates the Protein Kinase A (PKA) modulation of CACNA1H-containing Cav3.2 T-type calcium channels (4).
• Synonyms: CACNA1HB; Cav3.2; ECA6; EIG6; HALD4

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Calcium, Transmembrane
• Protein Pathways: Calcium signaling pathway, MAPK signaling pathway