GJB2 Rabbit Polyclonal Antibody

CAT#: TA349120

Rabbit Polyclonal Anti-GJB2 Antibody

Product Images

Western blot analysis of GJB2 in human colon tissue lysate with GJB2 antibody at (A) 1 and (B) 2 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GJB2 antibody was raised against a 16 amino acid peptide near the center of human GJB2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: GJB2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 25 kDa; Observed: 26 kDa
• Gene Name: gap junction protein beta 2
• Database Link:
  NP_003995
  Entrez Gene 2706 Human
  UniProt ID P29033
• Background: The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1). Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2). Other mutations in this gene have also been linked to a wide array of skin diseases (3).
• Synonyms: CX26; DFNA3; DFNA3A; DFNB1; DFNB1A; HID; KID; NSRD1; PPK

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane