EDA Rabbit Polyclonal Antibody

CAT#: TA349124

Rabbit Polyclonal Anti-EDA1 Antibody

Product Images

Western blot analysis of EDA1 in mouse kidney tissue lysate with EDA1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of EDA1 in mouse kidney tissue with EDA1 antibody at 5 ug/mL.

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  Immunofluorescence of EDA1 in mouse kidney tissue with EDA1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: EDA1 antibody was raised against an 19 amino acid peptide near the center of human EDA1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: EDA1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 16, 43 kDa; Observed: 39 kDa
• Gene Name: ectodysplasin A
• Database Link:
  NP_001005610
  Entrez Gene 13607 MouseEntrez Gene 302424 RatEntrez Gene 1896 Human
  UniProt ID Q92838
• Background: Ectodysplasin A (EDA1) is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation (1). It is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells and can be expressed as eight alternatively spliced isoforms in hair follicles and in the epidermis of adult skin (2,3). EDAs are required during development, and loss or mutation of EDA1 results in a group of developmental disorders identified as ectodermal dysplasia type 1 (4,5).
• Synonyms: ECTD1; ED1; ED1-A1; ED1-A2; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; STHAGX1; XHED; XLHED

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction