ATG4B Rabbit Polyclonal Antibody

CAT#: TA349127

Rabbit Polyclonal Anti-DTX4 Antibody

Product Images

Western blot analysis of DTX4 in HeLa cell lysate with DTX4 antibody at 1 ug/mL.

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  Immunohistochemistry of DTX4 in human spleen tissue with DTX4 antibody at 5 ug/mL.

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  Immunofluorescence of DTX4 in human spleen tissue with DTX4 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DTX4 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 68 kDa; Observed: 68 kDa
• Gene Name: autophagy related 4B cysteine peptidase
• Database Link:
  NP_847896
  Entrez Gene 66615 MouseEntrez Gene 23192 Human
  UniProt ID Q9Y4P1
• Background: The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).
• Synonyms: APG4B; AUTL1

Reference Data

• Protein Families: Protease
• Protein Pathways: Regulation of autophagy