Helicase SKI2W (SKIV2L) Rabbit Polyclonal Antibody

CAT#: TA349136

Rabbit Polyclonal Anti-SLC1A7 Antibody

Product Images

Western blot analysis of SLC1A7 in C2C12 cell lysate with SLC1A7 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of SLC1A7 in mouse kidney tissue with SLC1A7 antibody at 5 ug/mL.

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  Immunofluorescence of SLC1A7 in mouse kidney tissue with SLC1A7 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SLC1A7 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLC1A7.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SLC1A7 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 17, 52, 62, 68 kDa; Observed: 52 kDa
• Gene Name: Ski2 like RNA helicase
• Database Link:
  NP_008860
  Entrez Gene 108077 MouseEntrez Gene 6499 Human
  UniProt ID Q15477
• Background: The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1). More recent evidence indicates that is it widely expressed in peripheral tissues, also (2). Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3). In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4).
• Synonyms: 170A; DDX13; HLP; SKI2; SKI2W; SKIV2; SKIV2L1; THES2

Reference Data

• Protein Pathways: RNA degradation