TRIB3 Rabbit Polyclonal Antibody

CAT#: TA349143

Rabbit Polyclonal Anti-TRB3 Antibody

Product Images

Western blot analysis of TRB3 in mouse kidney tissue lysate with TRB3 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of TRB3 in mouse liver tissue with TRB3 antibody at 5 ug/mL.

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  Immunofluorescence of TRB3 in mouse liver tissue with TRB3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRB3 antibody was raised against a 17 amino acid peptide near the center of human TRB3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TRB3 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 39 kDa; Observed: 39 kDa
• Gene Name: tribbles pseudokinase 3
• Database Link:
  NP_001288117
  Entrez Gene 228775 MouseEntrez Gene 246273 RatEntrez Gene 57761 Human
  UniProt ID Q96RU7
• Background: TRB3 was initially identified as a novel kinase-like gene that was overexpressed in multiple human tumors and regulated by hypoxia (1). In the liver, TRB3 binds and inhibits AKT activity, leading to impaired insulin signaling (2), whereas in adipose tissue TRB3 is involved in the regulation of fatty acid oxidation through ubiquitination of Acetyl-CoA carboxylase (3). Endoplasmic reticulum (ER) stress induces TRB3 expression in skeletal muscle, leading to a decrease in insulin signaling and glucose uptake, suggesting that inhibition of TRB3 expression may be a potential therapeutic treatment for managing insulin resistance (4).
• Synonyms: C20orf97; NIPK; SINK; SKIP3; TRB3

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors