Adenosine A2b Receptor (ADORA2B) Rabbit Polyclonal Antibody

CAT#: TA349146

Rabbit Polyclonal Anti-ADORA2B Antibody

Product Images

Western blot analysis of ADORA2B in mouse colon tissue lysate with ADORA2B antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunohistochemistry of ADORA2B in rat colon tissue with ADORA2B antibody at 5 ug/mL.

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  Immunofluorescence of ADORA2B in rat colon tissue with ADORA2B antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ADORA2B antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ADORA2B. The immunogen is located within the last 50 amino acids of ADORA2B.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ADORA2B antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 37 kDa; Observed: 41 kDa
• Gene Name: adenosine A2b receptor
• Database Link:
  NP_000667
  Entrez Gene 11541 MouseEntrez Gene 29316 RatEntrez Gene 136 Human
  UniProt ID P29275
• Background: The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2). Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5). Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6).
• Synonyms: ADORA2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction