MALT1 Rabbit Polyclonal Antibody

CAT#: TA349149

Rabbit Polyclonal Anti-ADRM1 Antibody

Product Images

Western blot analysis of ADRM1 in EL cell lysate with ADRM1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of ADRM1 in human spleen tissue with ADRM1 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ADRM1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 45 kDa; Observed: 48 kDa
• Gene Name: MALT1 paracaspase
• Database Link:
  NP_006776
  Entrez Gene 240354 MouseEntrez Gene 307366 RatEntrez Gene 10892 Human
  UniProt ID Q9UDY8
• Background: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).
• Synonyms: IMD12; MLT; MLT1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway