Vinculin (VCL) Rabbit Polyclonal Antibody

CAT#: TA349159

Rabbit Polyclonal Anti-MKRN3 Antibody

Product Images

Western blot analysis of MKRN3 in human spleen tissue lysate with MKRN3 antibody at (A)1 and (B) 2 ug/mL.

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  Immunofluorescence of MKRN3 in human spleen tissue with MKRN3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MKRN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MKRN3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: MKRN3 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 55 kDa; Observed: 55 kDa
• Gene Name: vinculin
• Database Link:
  NP_003364
  Entrez Gene 22330 MouseEntrez Gene 305679 RatEntrez Gene 7414 Human
  UniProt ID P18206
• Background: The Makorin ring finger 3 (MKRN3) protein contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. The MKRN3 gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome (1), but a deletion of the gene does not (2). A deficiency of MKRN3 has been shown to cause central precocious puberty in humans (3).
• Synonyms: CMD1W; CMH15; HEL114; MV; MVCL

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton