SOX4 Rabbit Polyclonal Antibody

CAT#: TA349165

Rabbit Polyclonal Anti-SPIB Antibody

Product Images

Western blot analysis of SPIB in human prostate tissue lysate with SPIB antibody at 1ug/ml.

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  Immunohistochemistry of SPIB in human prostate tissue with SPIB antibody at 2.5ug/ml.

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  Immunohistochemistry of SPIB in human prostate tissue with SPIB antibody at 2.5ug/ml.

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  Immunofluorescence of SPIB in human prostate tissue with SPIB Antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SPIB antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SPIB. The immunogen is located within amino acids 200 - 250 of SPIB.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SPIB antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 19, 25, 29 kDa; Observed: 20 kDa
• Gene Name: SRY-box 4
• Database Link:
  NP_003098
  Entrez Gene 20677 MouseEntrez Gene 364712 RatEntrez Gene 6659 Human
  UniProt ID Q06945
• Background: SPIB is a member of the ETS transcription factor family that influences lymphoid development and activity and binds the consensus DNA site GGA (A/T) through a unique winged helix-turn-helix motif known as the ETS domain (1). SPIB is found in hematopoietic cells such as B cells and plasmacytoid dendritic cells (DC) (2,3). It promotes the development of plasmacytoid dendritic cells (pDCs) or natural interferon (IFN)-producing cells. SPIB may be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation (3,4).
• Synonyms: EVI16

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors