Ubiquitin D (UBD) Rabbit Polyclonal Antibody

CAT#: TA349174

Rabbit Polyclonal Anti-UBD Antibody

Product Images

Western blot analysis of UBD in human testis tissue lysate with UBD antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: UBD antibody was raised against a 16 amino acid peptide near the center of human UBD.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: UBD antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 18 kDa; Observed: 17 kDa
• Gene Name: ubiquitin D
• Database Link:
  NP_006389
  Entrez Gene 10537 Human
  UniProt ID O15205
• Background: UBD, also designated ubiquitin D or diubiquitin, plays a role in antigen presentation, cytokine response and apoptosis. It is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin (1,2). UBD is inducible by interferon gamma and TNF-alpha and regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (3). It may also regulate cell growth during dendritic cell or B cell activation and development (4,5).
• Synonyms: FAT10; GABBR1; UBD-3

Reference Data

• Protein Families: Druggable Genome