CARD4 (NOD1) Rabbit Polyclonal Antibody

CAT#: TA349198

Rabbit Polyclonal Anti-VTI1b Antibody

Product Images

Western blot analysis of VTI1b in HeLa cell lysate with VTI1b antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: VTI1b antibody was raised against a 17 amino acid peptide near the center of human VTI1b.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: VTI1b antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 14, 19, 26 kDa; Observed: 27 kDa
• Gene Name: nucleotide binding oligomerization domain containing 1
• Database Link:
  NP_006083
  Entrez Gene 107607 MouseEntrez Gene 500133 RatEntrez Gene 10392 Human
  UniProt ID Q9Y239
• Background: Vesicle transport through interaction with t-SNAREs homolog 1 (VTI1a and VTI1b) are involved in vesicular transport from the late endosomes to the trans-Golgi network (1). They are both localized in the trans-Golgi network, with VTI1a also found in the Golgi apparatus and VTI1b in endosomes (2,3). It is thought that VTI1b along with the SNARE protein VAMP8 mediates the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential process for autophagy (4).
• Synonyms: CARD4; CLR7.1; NLRC1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway