INPP4B Rabbit Polyclonal Antibody

CAT#: TA349199

Rabbit Polyclonal Anti-INPP4B Antibody

Product Images

Western blot analysis of INPP4B in 3T3 cell lysate with INPP4B antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: INPP4B antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 102 kDa; Observed: 100 kDa
• Gene Name: inositol polyphosphate-4-phosphatase type II B
• Database Link:
  NP_001095139
  Entrez Gene 116699 RatEntrez Gene 234515 MouseEntrez Gene 8821 Human
  UniProt ID O15327
• Background: Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3).
• Synonyms: MGC132014

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system