GAS 6 (GAS6) Rabbit Polyclonal Antibody

CAT#: TA349202

Rabbit Polyclonal Anti-GAS6 Antibody

Product Images

Western blot analysis of GAS6 in mouse heart tissue lysate with GAS6 antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GAS6 antibody was raised against a 19 amino acid peptide from near the amino terminus of human GAS6.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: GAS6 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 75 kDa; Observed: 75 kDa
• Gene Name: growth arrest specific 6
• Database Link:
  NP_000811
  Entrez Gene 14456 MouseEntrez Gene 58935 RatEntrez Gene 2621 Human
  UniProt ID Q14393
• Background: The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2). GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3). This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4). Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2).
• Synonyms: AXLLG; AXSF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein