Caspase 14 (CASP14) Rabbit Polyclonal Antibody

CAT#: TA349220

Rabbit Polyclonal Anti-CASP14 Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane 1-4: Jurkat cells A431 cells A549 cells A375 cells Primary antibody: TA349220 (CASP14 Antibody) at dilution 1/350 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Jurkat, A431, A549 and A375 cells
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human CASP14
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 28 kDa
• Gene Name: caspase 14
• Database Link:
  NP_036246
  Entrez Gene 23581 Human
  UniProt ID P31944
• Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
• Synonyms: MGC119078; MGC119079

Reference Data

• Protein Families: Druggable Genome