Inhibin beta A (INHBA) Rabbit Polyclonal Antibody

CAT#: TA349355

Rabbit Polyclonal Anti-INHBA Antibody

Product Images

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Mouse fat tissue, Primary antibody: (INHBA Antibody) at dilution 1/701, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

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  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using (INHBA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

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  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using (INHBA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 2000-5000, WB: 500-2000, IHC: 25-100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human INHBA
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 47 kDa
• Gene Name: inhibin beta A subunit
• Database Link:
  NP_002183
  Entrez Gene 16323 MouseEntrez Gene 29200 RatEntrez Gene 3624 Human
  UniProt ID P08476
• Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
• Synonyms: EDF; FRP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway