IQGAP3 Rabbit Polyclonal Antibody

CAT#: TA349360

Rabbit Polyclonal Anti-IQGAP3 Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Mouse lung tissue Primary antibody: TA349360 (IQGAP3 Antibody) at dilution 1/850 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 minute

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Mouse lung tissue
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human IQGAP3
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 185 kDa
• Gene Name: IQ motif containing GTPase activating protein 3
• Database Link:
  NP_839943
  Entrez Gene 404710 MouseEntrez Gene 128239 Human
  UniProt ID Q86VI3
• Background: IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson?s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
• Synonyms: MGC1947; MGC10170; MGC10831

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Regulation of actin cytoskeleton