ARMER (ARL6IP1) Rabbit Polyclonal Antibody

CAT#: TA349519

Rabbit Polyclonal Anti-ARL6IP1 Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human fetal liver tissue
  IHC: 50-200
  Positive control: Human breast cancer
  Predicted cell location: cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human ARL6IP1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ADP ribosylation factor like GTPase 6 interacting protein 1
• Database Link:
  NP_055976
  Entrez Gene 54208 MouseEntrez Gene 23204 Human
  UniProt ID Q15041
• Background: ARMER (apoptotic regulator in the membrane of the endoplasmic reticulum), also known as ADP-ribosylation-like factor 6-interacting protein 1 (ARL6IP1 or AIP1), is a multi-pass membrane protein that belongs to the Ras superfamily. It is expressed in brain, thymus, lung, bone marrow and, to a lesser extent, in spleen, kidney and liver. ARMER is not found in the heart and is found predominantly in early myeloid progenitor cells localizing to the intracytoplasmic membranes. It interacts with ARL6, inhibits caspase-9 activity by inhibiting proteolysis of downstream substrates (including LEHD-AFC, vimentin and caspase-3) and is down-regulated during myeloid differentiation. ARMER may play a role in membrane trafficking, protein transport or cell signaling during hematopoietic maturation.
• Synonyms: AIP1; ARL6IP; ARMER; SPG61

Reference Data

• Protein Families: Transmembrane