Sigma1 receptor (SIGMAR1) Rabbit Polyclonal Antibody

CAT#: TA349569

Rabbit Polyclonal Anti-SIGMAR1 Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 40 μg Lane 1-3: Mouse liver tissue Mouse brain tissue A549 cells Primary antibody: TA349569 (SIGMAR1 Antibody) at dilution 1/310 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 second

• 

  Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using TA349569 (SIGMAR1 Antibody) at dilution 1/50. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA349569 (SIGMAR1 Antibody) at dilution 1/50. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse liver and brain tissue, A549 cells
  IHC: 100-300
  Positive control: Human gasrtic cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human SIGMAR1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: sigma non-opioid intracellular receptor 1
• Database Link:
  NP_671513
  Entrez Gene 18391 MouseEntrez Gene 29336 RatEntrez Gene 10280 Human
  UniProt ID Q99720
• Background: This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
• Synonyms: ALS16; DSMA2; hSigmaR1; OPRS1; SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane