DCK Rabbit Polyclonal Antibody

CAT#: TA349644

Rabbit Polyclonal Anti-DCK Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 40 μg Lane: Mouse heart tissue Primary antibody: TA349644 (DCK Antibody) at dilution 1/550 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 second

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA349644 (DCK Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA349644 (DCK Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Mouse heart tissue
  IHC: 25-100
  Positive control: Human tonsil
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human DCK
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 31 kDa
• Gene Name: deoxycytidine kinase
• Database Link:
  NP_000779
  Entrez Gene 13178 MouseEntrez Gene 79127 RatEntrez Gene 1633 Human
  UniProt ID P27707
• Background: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
• Synonyms: MGC117410; MGC138632

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Purine metabolism, Pyrimidine metabolism