ASAH1 Rabbit Polyclonal Antibody

CAT#: TA349658

Rabbit Polyclonal Anti-ASAH1 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Human lung cancer tissue, human fetal brain and fetal lung tissue
  IHC: 50-200
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human ASAH1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: N-acylsphingosine amidohydrolase (acid ceramidase) 1
• Database Link:
  NP_004306
  Entrez Gene 11886 MouseEntrez Gene 84431 RatEntrez Gene 427 Human
  UniProt ID Q13510
• Background: This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.
• Synonyms: AC; ACDase; ASAH; PHP; PHP32; SMAPME

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysosome, Metabolic pathways, Sphingolipid metabolism