Estrogen Receptor beta (ESR2) Rabbit Polyclonal Antibody

CAT#: TA349939

Rabbit Polyclonal Anti-ESR2 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse brain tissue
  IHC: 50-200
  Positive control: Human cervical cancer
  Predicted cell location: Nucleus or Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human ESR2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: estrogen receptor 2
• Database Link:
  NP_001428
  Entrez Gene 13983 MouseEntrez Gene 25149 RatEntrez Gene 2100 Human
  UniProt ID Q92731
• Background: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
• Synonyms: ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors