Glucocorticoid Receptor (NR3C1) Rabbit Polyclonal Antibody

CAT#: TA350022

Rabbit Polyclonal Anti-NR3C1 Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Other products for "NR3C1"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: K562, 231, Hela, HepG2 cell, Mouse liver tissue, A172 cell, Jurkat cell, Mouse smooth muscle cell lysates
IHC: 50-200
Positive control: Human liver cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein of human NR3C1
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 86 kDa
Gene Name nuclear receptor subfamily 3 group C member 1
Background This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.
Synonyms GCCR; GCR; GCRST; GR; GRL
Reference Data
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways Neuroactive ligand-receptor interaction

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