IKBKE Rabbit Polyclonal Antibody

CAT#: TA350082

Rabbit Polyclonal Anti-IKBKE Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Raji cells
  IHC: 50-200
  Positive control: Human prostate cancer
  Predicted cell location: Cytoplasm or Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human IKBKE
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 80 kDa
• Gene Name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
• Database Link:
  NP_054721
  Entrez Gene 56489 MouseEntrez Gene 9641 Human
  UniProt ID Q14164
• Background: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).
• Synonyms: IKK-E; IKK-i; IKKE; IKKI

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway