KDM4D Rabbit Polyclonal Antibody

CAT#: TA350105

Rabbit Polyclonal Anti-KDM4D Antibody

Product Images

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human fetal brain tissue, Primary antibody: (KDM4D Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes

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  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (KDM4D Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

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  The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using (KDM4D Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 2000-5000, WB: 500-2000, IHC: 50-200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human KDM4D
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: lysine demethylase 4D
• Database Link:
  NP_060509
  Entrez Gene 55693 Human
  UniProt ID Q6B0I6
• Background: JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.
• Synonyms: JMJD2D