Leukotriene A4 hydrolase (LTA4H) Rabbit Polyclonal Antibody

CAT#: TA350144

Rabbit Polyclonal Anti-LTA4H Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Human fetal brain tissue Primary antibody: TA350144 (LTA4H Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA350144 (LTA4H Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA350144 (LTA4H Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human fetal brain tissue
  IHC: 25-100
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm and Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human LTA4H
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 69 kDa
• Gene Name: leukotriene A4 hydrolase
• Database Link:
  NP_000886
  Entrez Gene 16993 MouseEntrez Gene 299732 RatEntrez Gene 4048 Human
  UniProt ID P09960
• Background: LTA4H (Leukotriene A4-hydrolase ) is a Zn2+-containing enzyme with both epoxide hydrolase and aminopeptidase activity. As an epoxide hydrolase, LTA4H catalyzes the hydration of LTA4 to leukotriene B4 (LTB4, 5S,12R-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid), a potent lipid chemoattractant that influences inflammation, immune responses, and host defense against infection. As an aminopeptidase, LTA4H catalyzes the cleavage of amides of para-nitroaniline. The human LTA4H gene encodes a 610 amino acid protein.
• Synonyms: leukotriene A4 hydrolase

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Arachidonic acid metabolism, Metabolic pathways