PVRL4 (NECTIN4) Rabbit Polyclonal Antibody

CAT#: TA350224

Rabbit Polyclonal Anti-PVRL4 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: MCF7 cell lysate
  IHC: 100-200
  Positive control: Human liver cancer
  Predicted cell location: Secreted
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human PVRL4
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 55 kDa
• Gene Name: nectin cell adhesion molecule 4
• Database Link:
  NP_112178
  Entrez Gene 81607 Human
  UniProt ID Q96NY8
• Background: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
• Synonyms: EDSS1; LNIR; nectin-4; PRR4; PVRL4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Adherens junction