NUMB Rabbit Polyclonal Antibody

CAT#: TA350244

Rabbit Polyclonal Anti-NUMB Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: K562, hela, skov3, NIH/3T3 and Raji cells, human testis tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human NUMB
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 71 kDa
• Gene Name: NUMB, endocytic adaptor protein
• Database Link:
  NP_003735
  Entrez Gene 18222 MouseEntrez Gene 29419 RatEntrez Gene 8650 Human
  UniProt ID P49757
• Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
• Synonyms: C14orf41; c14_5527; S171

Reference Data

• Protein Pathways: Notch signaling pathway