prothymosin, alpha (PTMA) Rabbit Polyclonal Antibody

CAT#: TA350499

Rabbit Polyclonal Anti-PTMA Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 200-300
  Positive control: Human lung cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: prothymosin, alpha
• Database Link:
  NP_002814
  Entrez Gene 19231 MouseEntrez Gene 29222 RatEntrez Gene 5757 Human
  UniProt ID P06454
• Background: Prothymosin alpha (PTMA) is a nuclear protein possessing a number of cellular functions including cell survival. PTMA is identified to be localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brai. PTMA inhibits the neuronal necrosis induced by serum-free starvation or ischemia-reperfusion stress, which causes a rapid internalization of GLUT1/4, leading a decrease in glucose uptake and cellular ATP levels. Extensive research on PTMA showed that it is of clinical significance and potential medical use as they may serve as a molecular marker for cancer prognosis and/or as therapeutic agents for treating immunodeficiencies, autoimmune diseases and malignancies.
• Synonyms: TMSA

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors