VDAC3 Rabbit Polyclonal Antibody

CAT#: TA350600

Rabbit Polyclonal Anti-VDAC3 Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane: Mouse heart tissue Primary antibody: TA350600 (VDAC3 Antibody) at dilution 1/400 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 minutes

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Mouse heart tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 31 kDa
• Gene Name: voltage dependent anion channel 3
• Database Link:
  NP_005653
  Entrez Gene 22335 MouseEntrez Gene 83532 RatEntrez Gene 7419 Human
  UniProt ID Q9Y277
• Background: This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by
• Synonyms: HD-VDAC3; VDAC-3

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other
• Protein Pathways: Calcium signaling pathway, Huntington's disease, Parkinson's disease