HP1 gamma (CBX3) Rabbit Polyclonal Antibody

CAT#: TA350694

Rabbit Polyclonal Anti-CBX3 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: A375 and Raji cells, human fetal brain tissue
  IHC: 50-200
  Positive control: Human gasrtic cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CBX3
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 21 kDa
• Gene Name: chromobox 3
• Database Link:
  NP_057671
  Entrez Gene 12417 MouseEntrez Gene 11335 Human
  UniProt ID Q13185
• Background: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks.
• Synonyms: HECH; HP1-GAMMA; HP1Hs-gamma

Reference Data

• Protein Families: Druggable Genome, Transcription Factors