MOB4A (MOB1B) Rabbit Polyclonal Antibody

CAT#: TA350765

Rabbit Polyclonal Anti-MOB1B Antibody

Product Images

Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Jurkat cells, K562 cells, Primary antibody: (MOB1B Antibody) at dilution 1/112.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1000-2000, WB: 200-1000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human MOB1B
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: MOB kinase activator 1B
• Database Link:
  NP_001231695
  Entrez Gene 68473 MouseEntrez Gene 92597 Human
  UniProt ID Q7L9L4
• Background: The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
• Synonyms: MATS2; MOB4A; MOBKL1A