ARHGEF6 Rabbit Polyclonal Antibody

CAT#: TA350868

Rabbit Polyclonal Anti-ARHGEF6 Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA350868 (ARHGEF6 Antibody) at dilution 1/70 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA350868 (ARHGEF6 Antibody) at dilution 1/70, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC: 30-150
  Positive control: Human colorectal cancer
  Predicted cell location: Nucleus and Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ARHGEF6
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Rac/Cdc42 guanine nucleotide exchange factor 6
• Database Link:
  NP_004831
  Entrez Gene 9459 Human
  UniProt ID Q15052
• Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
• Synonyms: alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pancreatic cancer, Regulation of actin cytoskeleton