ARID1A Rabbit Polyclonal Antibody

CAT#: TA350871

Rabbit Polyclonal Anti-ARID1A Antibody

Product Images

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Lovo cells, A172 cells, Primary antibody: (ARID1A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1000-2000, WB: 200-1000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ARID1A
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 242 kDa
• Gene Name: AT-rich interaction domain 1A
• Database Link:
  NP_624361
  Entrez Gene 93760 MouseEntrez Gene 8289 Human
  UniProt ID O14497
• Background: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions.
• Synonyms: B120; BAF250; BAF250a; BM029; C1orf4; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1

Reference Data

• Protein Families: Druggable Genome