SMAD1 Rabbit Polyclonal Antibody

CAT#: TA350977

Rabbit Polyclonal Anti-SMAD1 Antibody

Product Images

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Mouse skeletal muscle tissue

• 

  The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (SMAD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

• 

  The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using (SMAD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1000-2000, WB: 200-1000, IHC: 50-200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human SMAD1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: SMAD family member 1
• Database Link:
  NP_005891
  Entrez Gene 17125 MouseEntrez Gene 25671 RatEntrez Gene 4086 Human
  UniProt ID Q15797
• Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation.
• Synonyms: BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1

Reference Data

• Protein Families: Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
• Protein Pathways: TGF-beta signaling pathway