Separase (ESPL1) Rabbit Polyclonal Antibody

CAT#: TA351169

Rabbit Polyclonal Anti-ESPL1 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Raji cells
  IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ESPL1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 233 kDa
• Gene Name: extra spindle pole bodies like 1, separase
• Database Link:
  NP_036423
  Entrez Gene 105988 MouseEntrez Gene 9700 Human
  UniProt ID Q14674
• Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.
• Synonyms: ESP1; SEPA

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Cell cycle, Oocyte meiosis