G protein coupled receptor 30 (GPER1) Rabbit Polyclonal Antibody

CAT#: TA351233

Rabbit Polyclonal Anti-GPER1 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: HepG2 cell lysate
  IHC: 50-100
  Positive control: Human gastric cancer
  Predicted cell location: Cytoplasm and Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human GPER1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 42 kDa
• Gene Name: G protein-coupled estrogen receptor 1
• Database Link:
  NP_001026852
  Entrez Gene 76854 MouseEntrez Gene 171104 RatEntrez Gene 2852 Human
  UniProt ID Q99527
• Background: This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
• Synonyms: CMKRL2; FEG-1; GPCR-Br; LERGU; LERGU2; MGC99678

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane