HSD17B1 Rabbit Polyclonal Antibody

CAT#: TA351268

Rabbit Polyclonal Anti-HSD17B1 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human placenta tissue
  IHC: 50-200
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human HSD17B1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 35 kDa
• Gene Name: hydroxysteroid (17-beta) dehydrogenase 1
• Database Link:
  NP_000404
  Entrez Gene 3292 Human
  UniProt ID P14061
• Background: Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.
• Synonyms: EDH17B2; EDHB17; HSD17; SDR28C1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Androgen and estrogen metabolism, Metabolic pathways