KIDINS220 Rabbit Polyclonal Antibody

CAT#: TA351326

Rabbit Polyclonal Anti-KIDINS220 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Raji and Hela cells
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human KIDINS220
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 197 kDa
• Gene Name: kinase D-interacting substrate 220kDa
• Database Link:
  NP_065789
  Entrez Gene 116478 RatEntrez Gene 57498 Human
  UniProt ID Q9ULH0
• Background: Ankyrin repeat-rich membrane-spanning protein (ARMS), also designated kinase D-interacting substance 220 or Kidins220, is a highly conserved protein containing multiple domains, including four putative transmembrane domains and several ankyrin repeats. ARMS is expressed in regions rich in neurotrophin (Trk) and ephrin (Eph) receptors, such as the brain and neuroendocrine cells (where it concentrates at the tip of neurites) and in plastic areas of the adult brain. It is also detected in peripheral blood immature dendritic cells and PC12 cells. ARMS functions as a substrate for protein kinase D and is a downstream target for both Trk and Eph receptors. It is a highly conserved protein, which suggests it has an evolutionary conserved role. The gene encoding for the protein maps to chromosome 2p24.
• Synonyms: ARMS

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Neurotrophin signaling pathway