RIZ1 (PRDM2) Rabbit Polyclonal Antibody

CAT#: TA351337

Rabbit Polyclonal Anti-PRDM2 Antibody

Product Images

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: MCF7 cells, Primary antibody: (PRDM2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

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  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using (PRDM2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

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  The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using (PRDM2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1000-2000, WB: 200-1000, IHC: 50-200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human PRDM2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 189 kDa
• Gene Name: PR domain 2
• Database Link:
  NP_056950
  Entrez Gene 7799 Human
  UniProt ID Q13029
• Background: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2

Reference Data

• Protein Families: Druggable Genome