MAL Rabbit Polyclonal Antibody

CAT#: TA351381

Rabbit Polyclonal Anti-MAL Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351381 (MAL Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351381 (MAL Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA351381 (MAL Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA351381 (MAL Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC: 25-100
  Positive control: Human gasrtic cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human MAL
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mal, T-cell differentiation protein
• Database Link:
  NP_002362
  Entrez Gene 4118 Human
  UniProt ID P21145
• Background: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
• Synonyms: mal; myelin and lymphocyte protein; T-cell differentiation protein; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein

Reference Data

• Protein Families: Transmembrane