Niemann Pick C1 (NPC1) Rabbit Polyclonal Antibody

CAT#: TA351458

Rabbit Polyclonal Anti-NPC1 Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351458 (NPC1 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351458 (NPC1 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human NPC1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NPC intracellular cholesterol transporter 1
• Database Link:
  NP_000262
  Entrez Gene 18145 MouseEntrez Gene 266732 RatEntrez Gene 4864 Human
  UniProt ID O15118
• Background: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.
• Synonyms: NPC

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome