SESN1 Rabbit Polyclonal Antibody

CAT#: TA351658

Rabbit Polyclonal Anti-SESN1 Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-5: Lovo cells hela cells K562 cells Raji cells hepg2 cells Primary antibody: TA351658 (SESN1 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 40 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Lovo, hela, K562, Raji and hepg2 cells
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human SESN1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 57 kDa
• Gene Name: sestrin 1
• Database Link:
  NP_055269
  Entrez Gene 140742 MouseEntrez Gene 27244 Human
  UniProt ID Q9Y6P5
• Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
• Synonyms: PA26; SEST1

Reference Data

• Protein Pathways: p53 signaling pathway