Tuberin (TSC2) Rabbit Polyclonal Antibody

CAT#: TA351875

Rabbit Polyclonal Anti-TSC2 Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane: A172 cells Primary antibody: TA351875 (TSC2 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 minutes

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA351875 (TSC2 Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA351875 (TSC2 Antibody) at dilution 1/20, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: PC3 cell and human colon cancer tissue
  IHC: 30-150
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human TSC2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 201 kDa
• Gene Name: tuberous sclerosis 2
• Database Link:
  NP_001070651
  Entrez Gene 22084 MouseEntrez Gene 24855 RatEntrez Gene 7249 Human
  UniProt ID P49815
• Background: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Synonyms: LAM; PPP1R160; TSC4

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, mTOR signaling pathway, p53 signaling pathway