VPS4B Rabbit Polyclonal Antibody

CAT#: TA351918

Rabbit Polyclonal Anti-VPS4B Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351918 (VPS4B Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351918 (VPS4B Antibody) at dilution 1/20, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human placenta tissue, PC3 cells and Human fetal liver tissue, HepG2, Hela, A431 and 293T cells
  IHC: 25-100
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human VPS4B
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: vacuolar protein sorting 4 homolog B
• Database Link:
  NP_004860
  Entrez Gene 9525 Human
  UniProt ID O75351
• Background: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.
• Synonyms: MIG1; SKD1; SKD1B; VPS4-2

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Endocytosis