IL12A Rabbit Polyclonal Antibody

CAT#: TA352753

Rabbit Polyclonal Anti-IL-12p70 Antibody

Specifications

Product Data

• Recommended Dilution: ELISA, ELISPOT, Neutralization assay, Western Blot
• Reactivities: Human, Rhesus Macaque
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: For immunization recombinant human IL-12p70 (CHO-derived) is used
• Formulation: Prior to lyophilization: 0.5 ml PBS + 125 mM trehalose.
• Concentration: lot specific
• Purification: Antibodies were sequentially purified by ammonium sulphate precipitation and protein A-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22.5 kDa
• Gene Name: interleukin 12A
• Database Link:
  NP_000873
  Entrez Gene 3592 Human
  UniProt ID P29459
• Background: The polyclonal antibody to human IL-12p70 neutralizes both natural and recombinant human and rhesus macaque IL-12 and IL-23 (van Beelen A.J. et al. 2007). The antibody has been used to skew Th2 polarization by blocking IL-12 which normally induces IFN-gamma production and stimulation of PBMC (Groot F. et al. 2006 and Kaptein B. et al. 2007). The is suitable for ELISA and ELISPOT assays and is affinity purified.
• Synonyms: CLMF; IL-12A; NFSK; NKSF1; P35

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus