Cytochrome P450 3A4 (CYP3A4) Mouse Monoclonal Antibody [Clone ID: F24P2B10]

CAT#: TA352868L

Mouse monoclonal Anti-Cytochrome P450 3A4 Clone F24 P2 B10

USD 1,140.00

9 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name F24P2B10
Applications IHC, WB
Recommended Dilution ELISA ; IHC ; WB
Reactivities Human
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Ovalbumin-conjugated synthetic peptide ESRDGTVSGA
Formulation PBS with 0.02% Sodium Azide
Concentration lot specific
Purification Purified by affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name cytochrome P450 family 3 subfamily A member 4
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
Synonyms CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, P450, Transmembrane
Protein Pathways Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.