Cytokeratin 5 (KRT5) Mouse Monoclonal Antibody [Clone ID: LH8]

CAT#: TA352876L

Mouse monoclonal Anti-Keratin5 & 14 Clone LH8

Specifications

Product Data

• Clone Name: LH8
• Recommended Dilution: IHC ; IF
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a, kappa
• Clonality: Monoclonal
• Immunogen: The 50,000 Mr band (including K14) was cut from an SDS-polyacrylamide gel and Triton X-100 extracted cytoskeleton pellet from cultured human foreskin keratinocytes.
• Formulation: PBS with 0.02% Sodium Azide
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: keratin 5
• Database Link:
  NP_000415
  Entrez Gene 3852 Human
  UniProt ID P13647
• Background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 5 and 14 are the predominant keratins in basal layer keratinocytes in stratified epithelia. Their expression is restricted to basal cells and are found on all keratinocytes. Keratin 14 is one of two keratins that distinguish stratifying epithelial cell types from simple epithelial cell types. Mutations in keratin 5 or 14 cause the skin blistering disorder epidermolysis bullosa simplex. LH8 may be useful as a basal cell marker and myoepithelial marker in stratified squamous or mixed epithelia.
• Synonyms: CK5; DDD; DDD1; EBS2; K5; KRT5A
• Note: For immunohistochemistry, use unfixed frozen sections with this antibody.