ADAM17 Rabbit Polyclonal Antibody

CAT#: TA352952L

Rabbit polyclonal anti-ADAM17 antibody

Product Images

Western blot analysis using Anti-ADAM17 antibody. α-PRO is the prodomain of ADAM17 fused to GST.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ADAM17
• Concentration: lot specific
• Purification: Unpurified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~120 kDa
• Gene Name: ADAM metallopeptidase domain 17
• Database Link:
  NP_003174
  Entrez Gene 11491 Mouse
  UniProt ID P78536
• Background: ADAM17 (TACE/CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis.
• Synonyms: ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE
• Note: Suggested dilution for western blot: 1:250

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway